Thermal Nociception in Rats Treated with Pulp and Extract of Noni Ethanolic (morinda citrifolia l.)

Bruna Teixeira Vidal, Priscila Drudi dos Santos, Halbannara Louyse de Pádua Teixeira, Wataro Nelson Ogawa, Katienne Brito Marcelino.

Abstract

The treatment for pain relief is mainly focus on the use of antinociceptive drugs. However, the current collection of DRUGS isn’t enough and many have side effects and adverse reactions that IMPOSSIBILITA their chronic use. Based on this problem, the article’s aim is to evaluate a supposed antinociceptive effect of Morinda citrifolia L in rats using hot plate assays (HPA) OBSERVANDO the latency time (LT) in the following groups: control (C); ethanolic pulp extract (EPE) and pulp extract (PE), in natura, both of noni; ascorbic acid (AA); diazepam (D); morphine (M) and the association diazepam-morphine (DM). In the post-30 min experiments with EPE and PE, there was a partial increase in TL with EPE equal to that observed after 20 min with PE. In the interval of 30 to 40 min, there was moderate tolerance to the thermal stimulus with PE that declined after 40 min, showing an antinociceptive tendency. The AA group showed a nociceptive effect during the first 30 min and at 40 min it showed a similar effect to the PE at the same time, indicating a moderate antinociceptive action. The results suggest a tendency that both EPE and PE have antinociceptive effects, although not significant, when compared to C, with PE having this effect a little more pronunced.