Topically Applied Anti-Inflammatory Properties of Medicinal Plants: A Systematic Review

Francisco Mayron de Sousa e Silva; Giovanna Carvalho da Silva, Rusbene Bruno Fonseca de Carvalho; Livio Cesar Cunha Nunes

Abstract

In this investigation of topically applied Brazilian medicinal plants for inflammation, the aim was to explore their anti-inflammatory properties, bridging scientific gaps and expanding natural therapeutic strategies. The study, conducted in April and May 2023, adhered to the PRISMA protocol, selecting articles from ScienceDirect and storing data in the StArt software. Analyzed studies highlighted taxonomic diversity and the topical application of plants, particularly leaves. Essential oils (EO) were frequently examined, revealing anti-inflammatory potential. Induced inflammatory edema was common for evaluating extracts, demonstrating modulatory effects on cytokines such as IL-10, TNF-α, and MPO, along with mediators like PGE2 and LTB4. The study acknowledged methodological and contextual limitations, enriching the discussion. It is concluded that extracts and EO exhibit promising anti-inflammatory properties, offering natural treatment options and potential for reducing the use of aggressive chemicals. The research underscores Brazilian biodiversity as a medicinal source and emphasizes the importance of environmental preservation.

Published
2023-12-09