Narrowband UVB Phototherapy: An Integrative Analysis of Clinical and Biochemical Benefits in Three Major Dermatoses

Sabrina de Araújo Nicoletti, Gabriel Correia Nedir Miranda, Rodrigo Artur Freiesleben, Mateus Silva Santos, Sávia Denise Silva Carlotto Herrera, Aline Alencar de Andrade Bressan

  • Sabrina de Araújo Nicoletti Universidade de Gurupi
  • Mateus Silva Santos Universidade de Gurupi
  • Sávia Denise Silva Carlotto Herrera Universidade de Gurupi
  • Rodrigo Artur Freiesleben Universidade de Gurupi
  • Gabriel Correia Nedir Miranda Universidade de Gurupi
  • Aline Alencar de Andrade Bressan Universidade de Gurupi

Abstract

Narrowband Ultraviolet B (NB-UVB) phototherapy is an established therapeutic modality
for the management of chronic inflammatory dermatoses such as vitiligo, psoriasis, and
atopic dermatitis. This integrative review aimed to assess the clinical and biochemical
efficacy of NB-UVB in patients affected by these conditions, based on original studies
published between 2020 and 2025. Included studies evaluated outcomes such as
repigmentation, reductions in PASI, EASI, and VASI scores, and changes in
inflammatory biomarkers. The findings demonstrated consistent improvements in
disease severity indices, enhanced quality of life, and relevant immunomodulatory
effects, including modulation of cytokine levels and autoantibodies. Despite the overall
efficacy, clinical responses varied according to lesion location, patient age, and presence
of comorbidities, highlighting the need for individualized treatment protocols. Gaps
remain regarding the response in specific subgroups and the in-depth understanding of
the underlying immunological mechanisms. It is concluded that NB-UVB is a safe and
effective therapeutic option, although further studies are warranted to deepen the
biochemical understanding and expand its clinical applicability across diverse patient
profiles.

Published
2025-12-05