Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease: First Cases Reported In The Brazilian Amazon:

Francisco Ribeiro Picanço Junior; Edrian Werner Carvalho; Francisco Benjamin Sousa Alves; Marcos Manoel Honorato; Randerson José de Araujo Sousa Sousa; Fernando Morgadinho Coelho

Creutzfeldt-Jakob Disease Creutzfeldt-Jakob Disease: First Cases Reported In The Brazilian Amazon

Creutzfeldt-Jakob Disease: First Cases Reported In The Brazilian Amazon

Francisco Ribeiro Picanço Junior State University of Pará https://orcid.org/0000-0002-7020-6608
Edrian Werner Carvalho State University of Pará https://orcid.org/0000-0002-1355-4681
Francisco Benjamin Sousa Alves State University of Pará (UEPA) https://orcid.org/0009-0005-9911-5506
Marcos Manoel Honorato State University of Pará (UEPA) https://orcid.org/0000-0002-9700-9938
Randerson José de Araujo Sousa Sousa State University of Pará (UEPA) https://orcid.org/0000-0003-3723-8955
Fernando Morgadinho Coelho Federal University of São Paulo (UNIFESP) https://orcid.org/0000-0002-8482-3754

Abstract

Objective: report three cases of Creutzfeldt-Jakob disease in the Amazon’s interior, demonstrate the evolution of the clinical picture and diagnosis of the disease, study the relationship between COVID-19 and the triggering or acceleration of the prion disease and analyze the difficulties for diagnosis. Methods: a series of cases composed of three patients with a condition compatible with Creutzfeldt-Jakob disease, where two of them were infected by the coronavirus. It is an observational and descriptive study and the data were collected from the medical records. Results: all three patients had an expected clinical picture for the condition, characterized by myoclonus and neurological decline in several functions, especially cognitive, behavioral, and cerebellar. Two of them had COVID-19, but it is unsure whether there is a relation between it and the triggering or an accelerated progression of the prion disease. In this study, all patients died from sepsis secondary to pneumonia within an interval of 3 to 9 months. Conclusion: The dissemination of knowledge about Creutzfeldt-Jakob disease and professional capacity may be relevant for a more assertive diagnosis in remote places such as the Amazon and its relationship with COVID-19 needs to be better elucidated.

Author Biographies

Francisco Ribeiro Picanço Junior, State University of Pará

MD, State University of Pará (UEPA)

Edrian Werner Carvalho, State University of Pará

MD, State University of Pará (UEPA).

Francisco Benjamin Sousa Alves, State University of Pará (UEPA)

Faculty of Medicine, State University of Pará (UEPA)

Marcos Manoel Honorato, State University of Pará (UEPA)

MD, PhD, Neurology and Neurosciences, Federal University of São Paulo (UNIFESP).

Randerson José de Araujo Sousa Sousa, State University of Pará (UEPA)

Postgraduate Program in Clinical Medicine, Federal University of Rio de Janeiro (UFRJ). Faculty of Medicine, State University of Pará (UEPA)

Fernando Morgadinho Coelho, Federal University of São Paulo (UNIFESP)

MD, PhD, Department of Neurology and Neurosurgery and Department of Psychobiology, Federal University of São Paulo (UNIFESP).

PDF (Português (Brasil))

Published

2024-03-05

Issue

Vol 12 No 1 (2024): Revista Amazônia: Science & Health

Section

Artigos

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