Desenvolvimento de pirulito de própolis sem açúcar para o tratamento de inflamação na orofaringe

Developement of a sugar-free própolis lollipop for the treatment of inflammation in the oropharynx

Abstract

The present study aimed to develop a sugar-free propolis-based lollipop intended to support the treatment of oropharyngeal inflammations. Propolis is widely recognized for its antimicrobial and anti-inflammatory properties, rendering it a natural and effective therapeutic agent. However, its characteristic bitter taste often compromises treatment adherence, particularly among pediatric populations. In this context, the formulation of a propolis lollipop represents an innovative approach to managing throat inflammation. A total of eight (8) formulation trials were conducted, utilizing isomalt, xylitol, and either dry extract or tincture of propolis, in addition to flavoring agents and bitterness-masking compounds. Quality control assessments were performed exclusively on the final formulation and included evaluations of appearance, pH, odor, taste, average weight, and dimensional parameters. The formulation designated PT8 demonstrated the most favorable organoleptic characteristics. The selection of dry propolis extract was critical in mitigating the inherent bitterness of the lollipop. With respect to quality control, the final formulation met all acceptable standards. Thus, the sugar-free propolis lollipop constitutes a viable, effective, and organoleptically acceptable alternative for the management of throat inflammations, while also representing a safe option for diabetic individuals due to the incorporation of non-glycemic sweeteners.